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虎撲體育,虎撲足球

2019年8月23日
[本篇訪問: 10725]
德國《應用化學》雜志向公眾專題介紹劉震教授課題組最新成果

7月3日,德國《應用化學》雜志刊出新聞稿(Press Release),以題目為“印跡球抗擊乳腺癌:分子印跡納米顆粒抑制腫瘤細胞表面人表皮生長因子受體2”(Imprinted Spheres Fight Breast Cancer: Inhibition of HER2 on tumor cells by molecularly imprinted nanoparticles)專題向公眾介紹了虎撲體育化學化工學院劉震教授在該刊發表的最新論文(Zhen Liu, et al. Inhibition of HER2-Positive Breast Cancer Growth by Blocking the HER2 Signaling Pathway with HER2-Glycan-Imprinted Nanoparticles. Angewandte Chemie International Edition, 2019, 10.1002/anie.201904860)。此前,該論文已被《應用化學》雜志選為熱點論文(hot paper)。該新聞稿等出后,美國科學促進會(AAAS)旗下的EurekAlert!等十余家科學傳播平臺和網站進行了轉載。

相關鏈接:

https://onlinelibrary.wiley.com/page/journal/15213773/homepage/press/201918press.html

https://www.eurekalert.org/pub_releases/2019-07/w-isf070319.php

“印跡”有識別受體分子HER2的專一位點的納米級顆粒為特別具有侵襲性、轉移形式的癌癥—HER2陽性乳腺癌的治療升起了新的希望。據中國研究人員在Angewandte Chemie的報道,該納米粒子與HER2的選擇性結合顯著抑制了腫瘤細胞的增殖。

乳腺癌是女性最常見的癌癥形式,也是導致死亡的主要原因之一。約20%至30%的乳腺癌病例涉及治療效果極差的HER2陽性。HER2指人表皮生長因子受體2,一種能識別和結合特定生長因子的蛋白質。HER2跨越細胞膜:一部分突出到細胞內部; 另一部分位于細胞表面。一旦與生長因子對接,HER2的胞外區就與第二個密切相關的HER家族成員,HER1或HER3,結合形成異質二聚體。這觸發了細胞內的多步信號級聯,其嚴重涉及細胞分裂,轉移和供應腫瘤的血管形成等過程。HER2陽性腫瘤細胞含有顯著的更高濃度的HER2。一種當前用于早期HER2陽性腫瘤治療的方法利用抗體與HER2結合以阻斷其二聚化。由南京大學(中國)的劉震領導的研究人員現已開發出“分子印跡”生物相容性聚合物納米粒子,它能夠像抗體一樣識別HER2,以阻止其二聚化。

該納米粒子可以通過分子印跡制備,簡言之,可聚合的混合物在稍后擬識別的(生物)分子的存在下聚合成納米球。該(生物)分子充當一種印章,在納米球中留下納米級的“印痕”。然后,這些印痕與用于印跡的分子完美地匹配從而專一性地與其結合。與抗體相比,該納米球容易生產、價廉且化學穩定。

對于印跡過程,研究人員使用特殊的方法(硼酸鹽親和可控定向表面印跡),這種方法特別可控,并且可以使用糖結構單元(聚糖)作為模板進行印跡。許多蛋白質含有特定的“糖鏈”。這些糖鏈是獨特的,就像蛋白質指紋一樣。研究人員使用這種來自HER2蛋白細胞外端的聚糖作為它們的“印章”。這使得它們能夠產生印跡納米顆粒,其特異性識別HER2并選擇性地結合HER2,并抑制二聚化。因此,它們能夠顯著減少體外腫瘤細胞的增殖和小鼠體內腫瘤的生長。相反,健康細胞基本上不受影響。

(化學化工學院 科學技術處)

原文如下:

Imprinted Spheres Fight Breast Cancer

Inhibition of HER2 on tumor cells by molecularly imprinted nanoparticles

Nanoscopic particles “imprinted” with specific binding sites for the receptor molecule HER2 raise hope for a new way of treating a particularly aggressive, metastasizing form of cancer: HER2-positive breast cancer. As reported by Chinese researchers in the journal Angewandte Chemie, the selective binding of the nanoparticles to HER2 significantly inhibits multiplication of the tumor cells.

Breast cancer is the most common form of cancer in women and one of the leading causes of death. About 20 to 30 % of breast cancer cases involve the very poorly treatable HER2-positive variety. HER2 stands for Human Epidermal Growth Factor Receptor 2, a protein that recognizes and binds to a specific growth factor. HER2 spans across the cell membrane: one part protrudes into the interior of the cell; the other is on the cell surface. As soon as a growth factor docks, the extracellular parts of HER2 bind into a heterodimer with a second, closely related HER, such as HER1 or HER3. This triggers a multistep signal cascade within the cell, which is critically involved in processes like cell pision, metastasis, and the formation of blood vessels that supply the tumor. HER2-positive tumor cells contain significantly higher concentrations of HER2. One current therapy for early-stage HER2-positive tumors is based on binding an antibody to HER2 to block the dimerization. Researchers led by Zhen Liu at Nanjing University (China) have now developed “molecularly imprinted” biocompatible polymer nanoparticles that recognize HER2 just as specifically as an antibody in order to prevent the dimerization.

Nanoparticles can be molecularly imprinted in that – to simplify – a polymerizable mixture is polymerized into nanospheres in the presence of the (bio)molecules they are supposed to recognize later. The (bio)molecules act as a kind of stamp, leaving nanoscopic “imprints” in the spheres. These then perfectly fit the molecules they were imprinted with and bind to them specifically. In contrast to antibodies, the nanospheres are easy and inexpensive to produce and are chemically stable.

For the imprinting process, the researchers use a special method (boronate affinity controllable oriented surface imprinting) that is particularly controllable and makes it possible to imprint using chains of sugar building blocks (glycans) as templates. Many proteins contain specific “sugar chains”. These are unique, like a protein fingerprint. The researchers used this kind of glycan from the extracellular end of the HER2 proteins as their “stamp”. This allowed them to produce imprinted nanoparticles that specifically recognize HER2 and selectively bind to it, inhibiting the dimerization. They were thus able to significantly reduce the multiplication of tumor cells in vitro and the growth of tumors in mice. In contrast, healthy cells were essentially unaffected.

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